Chemical Products 2-Bromopyridine Description
dark red liquid
Chemical Products 2-Bromopyridine Basic Attributes
Molecular Formula ：C5H4BrN
Molecular Mass ：158
Exact Mass ：156.952698
PSA ：12.9 A^2
H-bond Acceptor ：1
H-bond Donor ：0
Chemical Products 2-Bromopyridine Characteristics
Appearance ：Clear colorless to pale brown Liquid
Density ：1.657 g/mL at 25 °C(lit.)
Melting Point ：193°C
Bolling Point ：192-194 °C(lit.)
Flash Point ：130 °F
Refractive Index ：n 20/D 1.572(lit.)
Solubility ：Slightly miscible with water.
Storage Condition ：Refrigerator
Stability ：Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides.
Chemical Products 2-Bromopyridine Safety Information
Packing Group ：II
Hazard Class ：6.1
HS Code ：29333999
UN No. ：UN 2929 6.1/PG 2
Risk Code ：10-24/25-36/37/38-23/24/25-20/21/22
Safety Instructions ：16-36/37-45-38-36/37/39-28A-26
RTECS No. ：US3850000
Dangerous Mark ：T,Xn,F
Storage ：Treasury is ventilated, low temperature and dry; stored separately from food materials
P Code ：P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
Hazard Statements ：H301-H310-H315-H319-H335
Hazard Note ：Toxic
Flammability ：Thermal decomposition to emit toxic nitrogen oxides and bromide fumes
Toxicity ：Abdominal cavity-mouse LDL0: 31.3 mg/kg
Toxicity Class ：high toxic
Chemical Products 2-Bromopyridine Product Usage
2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.Organic synthesis, pharmaceutical intermediates. In the pharmaceutical industry, it is used to synthesize diisopropyramine (propylpyramine phosphate) for heart diseases. It is used as a pharmaceutical intermediate. It is one of the important chemical raw materials for dimethyl sulfate. It is an important methylating agent. It is used in chemicals, medicine, pesticides, military industry, dyes, spices.
Chemical Products 2-Bromopyridine Production Methods
Derived from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (above 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, then liquid bromine is added dropwise under salt bath freezing, the rate of addition is used to control the reaction temperature below -5°C Is appropriate. After the addition, dropwise add an aqueous solution of sodium nitrite, control the reaction temperature below 0°C, stir for 20-30 min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, collecting 88 ℃ -94 ℃/3333Pa distillate to obtain the finished product, the yield was 83.8%.
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