Tadalafil is also marketed in the pill form for treating erectile dysfunction as a generic medicine. Its brand named ‘Cialis’ was approved by FDA in US in the year 2003.Tadalafil is the third ED prescription drug approved by FDA after Sildenafil citrate and Vardenafil for treating erectile dysfunction. It is recommended as a “needed medicine”. It is a potent PDE-5 inhibitor.
What are the possible side effects?
The most common side effects experience by people using Tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy or runny nose. These symptoms usually subside after a few hours. Back pain and muscle aches can be experience by the person 12 to 24 hours after taking the drug, but it usually disappears after 48 hours.
What are the possible drug interactions?
Since the active component Tadalafil may cause transient low blood pressure (hypotension), a person should not take alkyl nitrites (poppers) for at least 48 hours after taking the last dose of Tadalafil. Using poppers during this time period may increase the risk of life-threatening hypotension.
The people who have consumed Generic Cialis within the last 48 hours cannot take organic nitrates to relieve angina, these patients should seek immediate medical attention if they experience chest pain.
How does it produce an action?
Generic Cialis 20mg has the longest half-life among all PDE-5 inhibitors about 17.5 hours, which contributes to its longer duration of action. Penile erection during sexual stimulation is produced as a result of increased penile blood flow. The increase in the blood flow is caused due to the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is facilitated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate more commonly known as cyclic GMP or cGMP in smooth muscle cells. cGMP is necessary for relaxation of smooth muscle and thus in turn increasing blood flow to the corpus cavernosum.The inhibition of phosphodiesterase type 5 (PDE5) improves the erectile function by increasing the amount of cGMP. Generic Cialis inhibits PDE5.
However, sexual stimulation is required to initiate the local penile release of nitric oxide, without it inhibition of PDE5 produced by Generic Cialis will have no effect.
The recommended starting dose of this medicine for most men is 10 mg, taken as required at least one hour prior to initiating sexual activity. The dose may be increased to 20 mg or decreased to 5 mg depending on its efficacy and the man's personal tolerance of the drug. Remember to take it just once in day.
Precautions to be taken
Take the medicine with water. Take the medicine as directed by the physician. You should inform your complete medical history to your physician. Do not crush, break or chew the tablet. This medicine can be taken with or without food. Avoid drinking alcohol while on treatment with this medicine. This medicine is not recommended for consumption by pregnant women and breast-feeding women.
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