Erectile Dysfunction (ED) is a common sexual disorder in men. A man with ED is not able to achieve or sustain a firm and strong penile erection during sexual intercourse. Management of erectile dysfunction with medicines is one of the simplest and effective way of treating erectile dysfunction. Sildenafil, Tadalafil, and Vardenafil are the most commonly administered medicines for the treatment of erectile dysfunction.
Tadalafil belongs to the class of medicines known as phosphodiesterase 5 (PDE-5) inhibitors. Tadalafil was approved for use by the Food and Drug Administration (FDA) on 21st November 2003 for the treatment of Erectile Dysfunction (ED). Tadalafil is the third ED prescription medicine after sildenafil citrate (Viagra) and Vardenafil (Levitra) used in treating ED. Tadalafil is available in different forms such as tablets, capsules, and jelly. The action of this medicine starts within 30-60 minutes of oral administration. The effect of this medicine lasts for an average duration of 36 hours. Tadalafil has a long half-life of 17.5 hours than other commonly prescribed PDE-5 inhibitors, which results in longer duration of action. It is not a habit-forming medicine.
The sexual stimulation in man triggers the release of the neurotransmitter known as nitric oxide (NO). The nitric oxide further stimulates the synthesis of cGMP. The function of the cGMP enzyme is the relaxation of smooth muscles inside the penile area and dilation of blood vessels supplying blood to the penile organ. There are eleven types of PDE present in human body. Of which, PDE-5 is predominately present in the penile region. The PDE-5 enzyme prevents the degradation of cGMP, thus causing an increase in the concentration of cGMP which relaxes and dilates the blood vessels increasing blood flow to the penile organ. This increased amount of blood flow to the penile region produce a firm and strong penile erection necessary for complete sexual satisfaction and complete sexual pleasure.
The most widely prescribed dose of Tadalafil is 20mg. Tadalafil is also available in strengths of 2.5mg, 5mg, and 10mg. It is to be taken only on demand. There must be a gap of 24 hours between two doses of Tadalafil. Tadalafil can be taken with or without food.
Tell your complete medical history to your doctor before starting this medicine. Do not consume Tadalafil if you are allergic to Tadalafil or any other PDE-5 inhibitor or if you are taking blood pressure lowering medicines, alpha blockers, and nitrate drugs as it can cause a severe drop in blood pressure. Do not consume alcohol and grapefruit juice while on treatment with Tadalafil as it may have undesirable consequences. The dose of Tadalafil should be adjusted in patients with severe liver and kidney dysfunction.
Use of this medicine is not recommended in men below 18 years of age. Tadalafil is to be used with caution in persons suffering from heart diseases, hearing and vision disorders.
The commonly observed side effects are nausea, headache, abdominal pain, and nasal congestion. These side effects subside after the drug is vanished from the body.
Seek immediate medical attention in case an overdose is suspected. The overdose symptoms include pain in the chest, nausea, irregular heartbeats and feeling light-headed feeling or fainting.
The long duration of action of Tadalafil helps the men to have a long-lasting satisfactory sexual activity. Thus, men prefer Tadalafil over other medicines for the treatment of erectile dysfunction.
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