Lincomycin—a good drug underestimated by farmers

Lincomycin is a lincosamide antibiotic produced by Streptococcus. Its antibacterial mechanism is to act on the ribosome of sensitive bacteria. By combining with the 50S subunit, it organizes the extension of the peptide chain and inhibits the synthesis of bacterial cell proteins. Therefore, its Belongs to antibacterial agents.
  Incompatibility of lincomycin
  At present, most of the diseases in pigs are mixed infections of bacteria and viruses, bacteria and bacteria, and viruses and viruses. Therefore, when treating swine diseases, several drugs are administered at the same time. It requires clinical front-line veterinarians to master the incompatibility of various drugs.
  1. Chloramphenicol (florfenicol) can replace lincomycin on the antibacterial target site, which affects the antibacterial effect of lincomycin, so lincomycin is the same as florfenicol and other chloramphenicols Drugs cannot be used at the same time.
  2. Lincomycin has an antagonistic effect when it is shared with macrolides (tilmicosin, tyvanectin, etc.).
  3. Lincomycin is incompatible with kanamycin, but lincomycin has a synergistic effect with gentamicin in aminoglycosides.
  4. Lincomycin will affect the bactericidal effect of penicillin and cephalosporin.
  Preparation, usage and dosage of lincomycin
  Currently on the market, lincomycin-related drugs include lincomycin hydrochloride injection, lincomycin hydrochloride soluble powder, spectinomycin hydrochloride lincomycin hydrochloride soluble powder.
  Lincomycin soluble powder usage and dosage: Calculated as lincomycin, per liter of water, mixed drink, 3g for chicken, 5-10 days in a row, 0.8-1.4g for pigs, 7 days in a row. However, it should be noted that both pigs and chickens have a drug withdrawal period of 5 days.
  Dosage of lincomycin injection: 30% lincomycin injection, intramuscular injection, once a day, 0.33ml per kilogram of body weight, once a day. The withdrawal period is 2 days.
  Spectinomycin hydrochloride lincomycin hydrochloride soluble powder (100g: spectinomycin 10g and lincomycin 5g) Dosage: based on this product, mixed drink, per liter of water, 2-3.2g for 5-7 day-old chicks , used continuously for 3-5 days.
  Antibacterial spectrum of lincomycin
  Lincomycin has a strong effect on Gram-positive bacteria, has an inhibitory effect on anaerobic bacteria, and has an effect on mycoplasma, but the effect is weak, and it is usually not sensitive to Gram-negative aerobic bacteria. Therefore, it is mainly used clinically for the treatment of Gram-positive bacteria and anaerobic bacteria.
  Clinical application of lincomycin in
  pigs Clinically, lincomycin can be used to treat Staphylococcus aureus, Streptococcus, pneumococcus, Mycoplasma hyopneumoniae, Mycoplasma suis synovium, Erysipelas suis, Leptospira and anaerobic Bacteria, the specific use refers to the following content:
  1. Treatment of Streptococcus suis
  a, Streptococcus arthritis, joint swelling of sick pigs, lameness, and a feeling of heat when touching the swollen joints. Treatment: Intramuscular injection of lincomycin hydrochloride on one side and gentamicin on the other side, once a day for 3 consecutive days.
  b. Streptococcus encephalitidis, the sick pig fell to the ground and paddled, unable to stand, or with crooked head and squinted eyes. Treatment: Intramuscular injection of lincomycin hydrochloride on one side and sulfadiazine sodium on the other side, once a day for 3 days in a row (for pigs with encephalitis lying on the ground, one injection of furosemide can be given intramuscularly first).
  2. Treatment of Staphylococcus aureus
  Staphylococcus aureus can cause exudative dermatitis in piglets, which mainly infects piglets, especially piglets aged 10-20 days. Poor sanitation in the pig house, piglets fighting and other factors that cause skin damage can induce the disease.
  After the onset, the piglets showed depression, weight loss, and anorexia. The head, ears, and eyes were the first to develop symptoms, and then gradually developed to the whole body. The skin showed yellow-brown oily exudates, and the skin temperature increased. Greasy. The mixed exudates such as skin flakes and dirt will form turtle-like scabs, and after the scabs fall off, red and swollen damage will be exposed.
  Treatment: sick piglets were bathed with 0.1% potassium permanganate solution, combined with oral glucose saline, and at the same time, intramuscularly injected lincomycin hydrochloride injection and dexamethasone on one side, and Houttuynia cordata injection and amoxicillin on the other side. The whole group of piglets without the disease were injected with long-acting ceftiofur intramuscularly once to prevent the disease.
  3. Prevention of swine mycoplasma pneumonia
  For sows from 3 days before delivery to 7 days after delivery, spectinomycin hydrochloride lincomycin hydrochloride is added to the feed at a dose of 400g/ton. Mycoplasma infection before the vaccine.
  4. Treatment of swine Clostridium welchii disease
  Clostridium welchii is the main cause of flatulence and death in pigs. In the early stage of the disease, the sick pigs stop defecation, the abdomen is round and round like a drum, the pigs have unbearable abdominal pain, restlessness when sitting up and down, shaking their heads and tails. Position for defecation, but unable to defecate. For the disease, the prevention and control measures are as follows:
  a. Lincomycin soluble powder + compound amoxicillin was administered to the whole group of pigs for 7 consecutive days. Then add the probiotics in the feed for 14 consecutive days.
  b. Infected pigs were fed or intramuscularly injected with metronidazole injection, and at the same time intramuscularly injected with lincomycin injection.
  c. For sick pigs with an acute course, find the acupuncture point according to the picture below, and use a large needle to deflate.

  5. Combined with the treatment of porcine infectious pleuropneumonia
  Porcine infectious pleuropneumonia will cause severe congestion and hemorrhage in the lungs of sick pigs, often secondary to mycoplasma pneumonia and anaerobic infection. It is recommended to use lincomycin when treating infectious pleuropneumonia, not only It can target anaerobic bacteria infection and also has a certain therapeutic effect on mycoplasma suis. Source: Sure enough pigs with severe disease: Intramuscular injection of Houttuynia cordata injection and ceftiofur sodium, followed by intramuscular injection of lincomycin 12 hours apart, once a day for 3 consecutive days.

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