Central Biohub

What are the miRNAs of FFPE tissue samples?   miRNA is the abbreviation of microribonucleic acid. These are the tiny non-coding RNAs controlling gene expression at the post-transcription phase. Protein synthesis is suppressed by binding to the untranslated region of the target RNA. However, the exact mechanism of this phenomenon needs to be better understood. Deregulation of miRNAs mediated gene expression adversely affects human health and leads to severe disease conditions. The studies on archived ffpe tissue sections of patient tissue contribute to understanding how miRNA functions.   Strength of microRNA in FFPE Tissues   FFPE sample preparation is a form of tissue preservation method to archive the patient's tissue samples for research. It is basically done to store the isolated tissue for longer years by forestalling tissue apoptosis and deterioration, keeping up with test respectability. As of late, microRNA dependability in FFPE tissues has acquired interest ... Continue reading →

The arrival of summer brings with it a stunning display of nature in all its green glory. For many of us, this season is a time to relish the warm weather and fresh air, whether that means spending time outside or going on a vacation. Unfortunately, summer can also bring seasonal allergies, often caused by pollens. These are tiny, lightweight powders or granules produced by plants for fertilization. During the spring and summer months, pollens from various grasses, flowers, weeds, and trees can be carried and spread by insects or wind, leading to allergic reactions in some individuals. Pollen allergy occurs when an allergic reaction is triggered by inhaling or coming into contact with pollen allergens. This condition, also known as hay fever, is a leading cause of acute asthma exacerbations. Common grass pollen allergy symptoms People allergic to pollen may experience the following symptoms when exposed to allergens. · Itchy, swollen, and watery eyes  · Cough and ... Continue reading →

Viral hepatitis refers to liver infections that can cause inflammation and damage to liver cells, causing severe life-threatening liver disease. These infections are caused by several viruses, including hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), hepatitis E (HEV), and hepatitis G (HGV). Classification of Hepatitis Diseases: Hepatitis diseases can impact individuals of all ages and genders. HAV and HEV are acute hepatitis with short-lived liver infections that usually resolve on their own and have a low fatality rate. They are transmitted through contaminated food or water and, once contracted, provide life-long immunity.  On the other hand, HBV and HCV can cause chronic liver infections, leading to severe health issues such as liver cirrhosis, liver failure, hepatocellular carcinomas, and even death. HDV and HGV are considered satellite viruses that often occur in individuals infected with hepatitis B or C. HBV and HCV are primarily spread through ... Continue reading →

Since 2019, the novel coronavirus, also known as COVID 19, has taken the world by storm, becoming a source of fear for people worldwide. The pandemic has devastated millions of lives and is considered one of the deadliest health crises in recorded history. The virus is caused by a mutated strain of coronaviruses known as SARS CoV 2 and is highly contagious, affecting individuals of all ages, genders, and ethnicities. Despite the rapid vaccine development, there is still no known cure for COVID 19, and scientists worldwide are working tirelessly to find a solution to end this global pandemic. How Does COVID-19 Spread? COVID-19 is a highly contagious respiratory illness that can be transmitted from person to person rapidly. The primary transmission mode is through the droplets or aerosols released into the air by an infected individual when they talk, sing, breathe, cough, or sneeze. Direct contact with an infected person's saliva or nasal secretions can also lead to virus ... Continue reading →

Oncology is the medical discipline that deals with diagnosing, treating, and studying cancers. In this modern era, the incidence of cancer has increased tremendously due to various external and intrinsic factors. But what exactly is Cancer? According to the definition, Cancer is a condition where body cells grow and multiply uncontrollably, resulting in spreading to other body parts through the blood and lymph system. It can start anywhere in the body. According to epidemiological studies, cancer is the second leading cause of death and disability in the world. Causes of Cancer:  Several factors are known to cause cancer diseases. However, the exact reason for cancer is the mutation of DNA within cells. Genetic mutation results in the following mechanism to cause cancer: Stimulate abnormal growth and proliferation of abnormal cells Failure to stop uncontrolled cell growth due to mis regulated tumor suppressor genes. Make mistakes while repairing DNA errors. Types of ... Continue reading →

High blood cholesterol is now regarded as the disease of the new millennium. Millions of people worldwide struggle with high cholesterol. But what does the term "high cholesterol disease" really mean? Let's examine this situation closely.  Hyperlipidaemia, a chronic disease condition marked by high blood cholesterol levels, is brought on by an overabundance of lipids and fats in the blood. It is one of the main diseases of modern life brought on by poor eating patterns and inactivity. The main factor causing hyperlipidemia is the excessive consumption of saturated fats. Severe health and circulatory conditions may develop if it is not treated. Tips to control high cholesterol levels An individual with hyperlipidemia has higher blood levels of triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL cholesterol or good cholesterol) have a higher risk of these substances accumulating in the arteries and obstructing them. Hyperlipidemia is the ... Continue reading →

Monkeypox is a rare and potentially serious disease caused by the Monkeypox virus. It is similar in symptoms to smallpox and is primarily found in nonhuman primates and rodents, but it can also be transmitted to humans. The incubation period is 5 to 21 days, and symptoms can include fever, skin rash, chills, muscle pain, fatigue, and swollen lymph nodes. The skin rash starts on the face, hands, or legs and spreads to other parts of the body, starting as flat and then developing into blister-filled lesions that eventually scab over. In the past year, monkeypox outbreaks have been reported in non-endemic countries like the US, UK, and Europe, leading to its declaration as a Public Health Emergency of International Concern. In response, health authorities are calling for increased research into vaccines and treatments to combat the spread of the disease. Use of Human Biospecimens in Research  Human biospecimens play a critical role in current medical research, particularly in ... Continue reading →

Know about vector borne diseases The infectious disorders known as "vector-borne diseases" are spread by biting small infected blood-sucking insects (vectors), such as mosquitoes, flies, bugs, ticks, etc. It is one of the major public health issues in developing or undeveloped countries. Measures have been conducted for a long time to avoid or eliminate such vector-borne diseases. However, the disease's occurrence is growing more widespread every year. World health organization states that the Eastern Mediterranean, Southeast Asia, and Africa are the regions with the highest morbidity and mortality rates due to higher disease prevalence. Commonly seen vector borne disease: Mosquitoes are the first animal that springs to mind when we hear about an insect that spreads diseases. Therefore, it is unsurprising that the primary means through which vector-borne diseases are spread is mosquito bites. Malaria, Dengue fever, Chikungunya, West Nile disease, Chagas disease, Zika ... Continue reading →

COVID 19, caused by the novel Coronavirus, was declared a global pandemic by WHO on March 11, 2020. Two years later, the virus spreads globally, with daily reports of millions of new infections. New mutated strains have emerged, labelled as Virus Variants of Concern (VOC), including Alpha, Beta, Gamma, Delta, and Omicron. Despite efforts to control the spread, COVID 19 remains a pandemic with ongoing infection rates. The virus has dramatically impacted all aspects of life, including social, economic, and public health. It is crucial to conduct more studies on the pre and post-pandemic health of the population. Use of Pre-pandemic Human Biospecimens in Research  Pre-pandemic biospecimens are a collection of clinical research samples from healthy donors worldwide. These samples include SARS-CoV-2-free human serum, plasma, and whole blood in various media, collected and tested for infectious diseases before the COVID 19 outbreak in 2019. These samples are exclusively for research ... Continue reading →

Rheumatoid arthritis is a chronic autoimmune disorder that affects millions of people worldwide. It is characterized by the missregulation of humoral and cell-mediated immunity, leading to the development of antibodies that attack the joints. The causes of this disorder are not fully understood. The impact of rheumatoid arthritis on the body is significant, as it causes inflammation and swelling in the lining of joints, leading to bone erosion, destruction of synovial joints, and structural changes in the joints. Due to this, individuals with rheumatoid arthritis may find it difficult to perform daily activities such as walking, sitting, standing, and running. Women and those with a family history of rheumatoid arthritis are more susceptible to developing the disorder. If not treated effectively, acute rheumatoid arthritis can progress to chronic arthritis, leading to severe disability, premature ageing, and increased mortality. Additionally, rheumatoid arthritis can significantly ... Continue reading →

What is Coeliac Disease? A chronic autoimmune condition called celiac disease is brought on by eating things that contain gluten and results in inflammation and damage to the small intestine. Grass proteins like wheat, barley, and rye are exceptionally high in gluten. One of the most common hereditary illnesses affects millions of people in European countries. However, the celiac disease causes are still unclear. When a person with celiac disease consumes foods containing gluten, an abnormal adaptive immune response occurs, which causes enteropathy. Due to the resulting damage to the villi that support the intestinal mucosal surface, indigestion and nutrient malabsorption occur.  Ways to manage Coeliac Disease? Celiac disease cannot be completely cured. Therefore, preventing the occurrence of the disease is the main priority rather than celiac disease treatment. The foundation for managing celiac disease symptoms is strict adherence to a gluten-free diet or completely avoiding ... Continue reading →

Pregnancy is a vital time for women, marking physical and emotional changes leading up to the birth of a healthy baby. It is divided into three trimesters, spanning nine months. Maternal health is of utmost importance, as it directly affects the developing fetus. However, treating illnesses during pregnancy can be difficult as there is limited evidence on the safety of many treatments for this special population. Pregnant women, fetuses, and newborns are subject to various regulations to protect them. Hence, in-vitro experiments using clinical specimens such as urine, serum, plasma, and whole blood from pregnant women are crucial for advancing clinical research. Despite this, collecting specimens from pregnant women presents its own set of challenges.   Collection of Clinical Samples from Pregnant Women: Challenges  Obtaining clinical samples from pregnant women for research purposes can present various difficulties, such as:  ● Declining to participate in clinical ... Continue reading →

What are autoimmune diseases? Autoimmune diseases are rare disease conditions in which the body's immune system attacks and destroys it's healthy tissues, leading to chronic conditions. These diseases affect millions of people worldwide, with a higher incidence among women and sudden onset at any age. There are over 80 autoimmune diseases known, including Hashimoto's thyroiditis or , Hashimoto disease, lupus disease, psoriasis, multiple sclerosis, coeliac disease, etc Autoimmune disease biospecimen helps in research on autoimmune Diseases. The increasing list of autoimmune diseases has prompted global research to focus on finding new treatments and preventing these diseases. Currently, a lack of clear understanding of the causes and exact mechanisms of autoimmunity is a major obstacle in finding a cure for autoimmune conditions. To overcome this challenge, it is crucial to use human biospecimens such as serum, plasma, tissue, and PBMC from patients with autoimmune diseases. ... Continue reading →

What is the TORCH test in pregnancy? TORCH testing is a crucial component of prenatal care during pregnancy. The purpose of this test is to detect and diagnose infections and congenital disorders that may be harmful to both the mother and the fetus. The test is designed to identify the presence of Toxoplasma gondii, Rubella, Cytomegalovirus, and Herpes simplex virus, all of which can cause serious complications during pregnancy. The test is typically performed in the first trimester and is considered a sensitive and accurate screening method. It is imperative in areas with a high incidence of these infections. Regular prenatal checkups and testing are essential to maintain the mother's and growing fetus's health and well-being. TORCH screening during pregnancy can identify infections or disorders that Toxoplasma gondii, Rubella, Cytomegalovirus, and Herpes simplex virus may cause. This test involves a simple blood draw and is considered a reliable and precise method for ... Continue reading →

Take a look at autoimmunity. The prevalence of autoimmune conditions has increased tremendously in the past few years. Autoimmune disorders refer to a cluster of disorders caused by a misregulated immune system producing autoantibodies that mistakenly target healthy bodily tissues and eventually destroy them while impairing their ability to function normally. These dreadful diseases affect millions of individuals globally and significantly reduce their quality of life. Common types of autoimmune diseases include Rheumatoid arthritis, celiac disease, autoimmune thyroid issues, inflammatory bowel disease, SLE, myasthenia gravis, etc.    Central BioHub Contribute to Strengthen Research to Fight Autoimmunity A wide variety of Autoimmune disease samples gathered from thousands of individuals with autoimmune disease symptoms are available from Central BioHub, which is fuelling the latest research on autoimmune diseases. Patient samples serve as human in-vitro models to increase ... Continue reading →

What Exactly is a Biorepository?   A biobank, often referred to as a biorepository, is a facility specifically designed to house human specimens and related data for research. It is a collection of numerous human samples that are yet to be studies in order to produce the latest in human diagnostic and medical technology. Biorepositories' primary duties include gathering, processing, storing, and disseminating priceless human biospecimens for scientific study. Biobanks preserving samples for a long years without compromising their quality and integrity.   Role of human biospecimens for research   Modern clinical research prioritizes increased studies on a variety of genetically varied human samples due to pressing need for individualized therapy. This aids scientists in comprehending the precise causes, course, and effects of diseases, as well as any variations brought on by interindividual differences. To support successful research endeavors, it is crucial to have ... Continue reading →

What are human biospecimens? Human biospecimens are crucial in research as they provide valuable biological material that can be used to study disease processes, test new treatments and diagnostic methods, and advance our understanding of human health and disease. It includes blood, tissue, urine, saliva, and other bodily fluids, and they can be collected from patients with a wide range of conditions, including cancer, infectious diseases, and autoimmune disorders. Human biospecimens can be analyzed to identify markers of disease, determine the presence of specific viruses or bacteria, and assess the effectiveness of new treatments. By using human bio specimens, researchers can study real-life examples of disease, making their findings more relevant and meaningful. Additionally, by collecting biospecimens from diverse populations, researchers can gain a better understanding of how diseases affect different groups of people, which can inform personalized and effective treatments. In ... Continue reading →

Every human is unique and repeatable. Promoting translational and precision medicine research on human cells is paramount to discovering individualized treatments for human disease states. Cytology is the branch of science related to examining and experimenting with human cells. It is also known as human cell biology or Human cell research. Cytology testing is widely used to diagnose, screen and study certain diseases like cancer, autoimmune diseases, rare disease conditions, etc. Generally, human cells are isolated from bodily fluids like urine samples, tissue scrapings used in cervical smears or biopsy samples,  fine-needle aspirations, and cerebrospinal fluid tapping is done for disease diagnosis, monitoring or research. Discover the largest high-quality cell products by perusing our current cytology sample inventory here. For experimental research to create next-generation therapeutics and diagnostic tools, we provide a wide variety of human cells, including peripheral blood ... Continue reading →

What are human biospecimens? Human biospecimens refer to any natural substances that are derived from the human body collected for disease diagnosis, treatment, monitoring, and research. It consists of human serum, plasma, whole blood, cerebrospinal fluids, semen, nasal secretions, urine, tissues, organs, faeces, etc., but are not limited to these. Human biospecimens are also known as human biological specimens, biosamples, biomaterials, and human specimens.  Usually, human biospecimens are collected from patients or donors during any clinical or diagnostic procedure, such as laboratory testing, biopsies, surgery, etc. After diagnosis, the residual human bio specimens are not discarded; instead are stored in a variety of sophisticated biobanks and biorepositories for future research use.  Central BioHub Provides Instant to Millions of Human Biospecimens Online Since 2017, Central BioHub has been one of the top suppliers of trustworthy human biospecimens for research for ... Continue reading →

What exactly are musculoskeletal diseases? The term "musculoskeletal diseases" refers to a cluster of illnesses that affect the body's musculoskeletal system, which consists of the bones, muscles, tendons, ligaments, spine, blood vessels, and nerves that affect how the body moves.  The most prevalent musculoskeletal conditions include tendonitis, ligament sprains, osteoarthritis, osteoporosis, sarcopenia, osteopenia, gout, ankylosing spondylitis, rheumatoid arthritis, and carpal tunnel syndrome. Hospital visits and the need for rehabilitation to restore bone health have increased globally over the past ten years due to an increase in the burden of musculoskeletal diseases in the world's population.   What exactly are connective tissue diseases? Connective tissue disorders are conditions that harm the body's connective tissues and result in inflammation and the degradation of nearby proteins and structures. Numerous connective tissue disorders impacting ... Continue reading →