Central Biohub

A snapshot of the present clinical research landscape.   Healthcare and diagnostics research has gained momentum in the past century, with researchers worldwide striving to discover new and cost-effective clinical trial methods without compromising quality. With growing competition among pharmaceutical companies, there is a pressing need to increase the volume of clinical research and trials. Clinical trials that involve human participants are riskier and more expensive for sponsors. Additionally, enrolling the appropriate study group, retaining participants from study start to finish, and conducting prospective follow-ups can pose significant challenges and cost cumbersome. Human biospecimens, such as serum, plasma, urine, CSF, stool, and tissue collected from patients, can serve as in-vitro human models for clinical research developments in this context. These biospecimens can provide valuable insights into the biology of diseases and their response to treatments without the ... Continue reading →

Alzheimer's is a neurological disorder characterized by brain atrophy that can lead to severe memory loss. It is the leading cause of dementia worldwide, as patients gradually lose their cognitive abilities and other mental skills, eventually becoming unable to function independently. While family history and advancing age are among the most significant risk factors for Alzheimer's disease, its specific cause remains uncertain. Nevertheless, it is a major illness associated with ageing and impacts millions of individuals globally. Alzheimer's disease causes Research efforts are underway globally to uncover the precise aetiology of Alzheimer's disease. Nonetheless, the most prominent determinant influencing disease progression is age, as individuals over 65 are at a greater risk of developing the condition than younger adults. Additionally, having a family history of the disease is strongly associated with its incidence. Other extrinsic factors, such as diet, lifestyle, ... Continue reading →

Parkinson's disease is a condition that can severely impact a person's life. It causes a range of symptoms, including shaking, stiffness, difficulty balancing, and coordination issues. This disease is caused by the death of specific neurons in the brain, which leads to the formation of Lewy bodies and motor impairment. The condition is also known as parkinsonism. Despite many years of research, we still need to understand the cause of this disease fully. Unfortunately, the prevalence of Parkinson's disease is on the rise, making it more important than ever to find better diagnostic tests and effective treatments.   What are Parkinson's disease symptoms?   Parkinson's disease is a progressive disorder with symptoms worsening over time. Early signs of Parkinson's disease include tremors while at rest, rigid limbs and trunks, slow movement, and balance problems. As the disease advances, individuals may experience difficulty with swallowing, walking, ... Continue reading →

Peripheral Blood Mononuclear Cells (PBMCs) are a group of blood cells such as lymphocytes (T-cells, B-cells and NK cells), monocytes, and dendritic cells that play an essential role in modulating immunity in humans. It is also known as agranulocytes. PBMCs defend the body against cancer and other human pathogenic diseases and infections. How are Peripheral Blood Mononuclear Cells produced? Peripheral Blood Mononuclear Cells are produced from haematopoietic stem cells in the bone marrow by the process of haemopoiesis. During hematopoiesis, the cells differentiate to form distinct lineages called myeloid and lymphoid. PBMCs are released into the peripheral bloodstream to promote immunity; they normally contain rounded single-nucleated lymphoid cells and specific myeloid cells. In the fight against bacteria, viruses, fungi, and other external invaders of the human body, these cells serve as the immune system's main engine. PBMCs serve as our body's first line of defence. ... Continue reading →

Today, human tissue banking offers a wide range of opportunities and is essential to contemporary medical research. The specialized, licensed facilities known as tissue banks gather, process, store, and distribute human tissues for clinical transplantation, medical research, and educational purposes. Tissue banking is an idea that is as old as skin grafting itself. Typically, human tissues specimens for banking are obtained from the human body while the patient is still alive during a clinical procedure, a biopsy, or surgery. The tissue samples may occasionally be taken from individuals who have died. After being examined, the collected human tissues are prepared for usage in sterile cryogenic units by processing and preserving them in tissue banks. Additionally, rigorous quality control is used to preserve the integrity of the samples and stop tissue damage due to natural processes like necrosis and apoptosis.  Use of Human Tissue Samples This age has seen a rise in the ... Continue reading →

Today, human tissue banking offers a wide range of opportunities and is essential to contemporary medical research. The specialized, licensed facilities known as tissue banks gather, process, store, and distribute human tissues for clinical transplantation, medical research, and educational purposes. Tissue banking is an idea that is as old as skin grafting itself. Typically, human tissues specimens for banking are obtained from the human body while the patient is still alive during a clinical procedure, a biopsy, or surgery. The tissue samples may occasionally be taken from individuals who have died. After being examined, the collected human tissues are prepared for usage in sterile cryogenic units by processing and preserving them in tissue banks. Additionally, rigorous quality control is used to preserve the integrity of the samples and stop tissue damage due to natural processes like necrosis and apoptosis.  Use of Human Tissue Samples This age has seen a rise in the ... Continue reading →

The COVID-19 pandemic affected nearly every aspect of the lives of people worldwide. Caused by a virus outbreak in December 2019, the coronavirus SARS-CoV-2 has since then posed a significant threat to global health. Due to the rapid development and distribution of COVID-19 vaccines, this devastating disease could fortunately be stopped resulting in the end of the global pandemic in May 2023. COVID-19 is characterized by symptoms that range from mild respiratory issues to severe pneumonia and even take lethal courses in some cases. The virus primarily spreads through respiratory droplets exhibited by coughing and sneezing, which made mask-wearing, social distancing, and hand hygiene essential preventive measures during the pandemic. However, the most effective tool proven had been the COVID-19 vaccination which effectively led to the end of the global pandemic. COVID-19 vaccines have been with unprecedented speed due to significant advances in vaccine technology and global ... Continue reading →

A biobank is a specialised facility that gathers, preserves and distributes priceless human biospecimens with associated data for clinical and experimental research. It also goes by the name "biorepositories."  It is two types based on ownership and governance ie, public biobanks and commercial biobanks. Public biobanks own by governmental biomedical research organisations, universities or non-profitable research centres. On the other hand, commercial biobanks are owned by CROs and other profitable organisations. Let us see what exactly are human biospecimens or human samples.   Any substances derived from the patient or consented donors, such as blood, urine, tissues, organs, cells, DNA, hair, teeth, bones, etc., gathered during clinical procedures such as treatment or diagnosis are referred to as human biomaterials or human biological materials. Human biobanks are specially constructed facilities where the collected human specimens are obtained for ... Continue reading →

Triple Negative Breast Cancer (TNBC) is a type of breast cancer that can become challenging in terms of both diagnosis and treatment. In comparison to other forms of breast cancer, TNBC lacks three crucial receptors, namely the estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2/neu).  Since these receptors are also used for breast cancer treatment, the absence of these receptor targets makes TNBC more aggressive and limits the treatment options. Therefore, new treatment approaches and diagnostic approaches are needed. The diagnosis of TNBC typically involves a combination of techniques such as mammography, ultrasound, biopsy, and immunohistochemistry. The absence of ER, PR, and HER2/neu receptors is especially confirmed through immunohistochemical tests which allow the distinguishment of TNBC from other breast cancer subtypes. However, precise diagnosis is not trivial as TNBC shares symptoms with other breast cancers as well. ... Continue reading →

What are human biospecimens? Human biospecimens are crucial in research as they provide valuable biological material that can be used to study disease processes, test new treatments and diagnostic methods, and advance our understanding of human health and disease. It includes blood, tissue, urine, saliva, and other bodily fluids, and they can be collected from patients with a wide range of conditions, including cancer, infectious diseases, and autoimmune disorders. Human biospecimens can be analyzed to identify markers of disease, determine the presence of specific viruses or bacteria, and assess the effectiveness of new treatments. By using human bio specimens, researchers can study real-life examples of disease, making their findings more relevant and meaningful. Additionally, by collecting biospecimens from diverse populations, researchers can gain a better understanding of how diseases affect different groups of people, which can inform personalized and effective treatments. In ... Continue reading →

Disease incidence and prevalence have reached unprecedented heights in today's fast-changing world, driving up the demand for cutting-edge medical research to develop the next generation of treatments and diagnostics for better disease management. Any medical discovery begins with human biosamples collected from patients. To advance studies and accomplish study targets, researchers must gather compatible human specimens from the target population, including healthy donors and patients, in the right quantity and quality. Ironically, this is frequently the most time-consuming part of the entire research process. After spending extra time looking for study specimens, researchers often come up with nothing. On the other hand, human biological materials are accumulating in several biobanking facilities without being used for any research. What is the solution for this? Knowing this to be accurate, we decided to streamline the acquisition of biological specimens. Therefore, we ... Continue reading →

What Exactly is a Biorepository?   A biobank, often referred to as a biorepository, is a facility specifically designed to house human specimens and related data for research. It is a collection of numerous human samples that are yet to be studied in order to produce the latest in human diagnostic and medical technology. Biorepositories' primary duties include gathering, processing, storing, and disseminating priceless human biospecimens for scientific study. Biobanks preserving samples for a long years without compromising their quality and integrity.   Role of human biospecimens for research   Modern clinical research prioritizes increased studies on a variety of genetically varied human samples due to pressing need for individualized therapy. This aids scientists in comprehending the precise causes, course, and effects of diseases, as well as any variations brought on by interindividual differences. To support successful research endeavors, it is crucial to have ... Continue reading →

Hashimoto's thyroiditis, also known as chronic autoimmune thyroiditis, is a persistent autoimmune disorder that affects the normal functioning of the thyroid gland. It is caused by the abnormal immunological processes known as cell- or antibody-mediated destroy the healthy cells of the thyroid gland, resulting in increased fibrosis and a decrease in the synthesis and release of thyroid hormones into the bloodstream. The underlying causes of this autoimmune condition are not fully understood, and ongoing research is underway worldwide to understand the disease's pathophysiology and triggers.   Know the symptoms of Hashimoto's disease.   Hashimoto's thyroiditis is a leading cause of autoimmune thyroiditis or hypothyroidism in developed countries. This condition impairs the normal production and synthesis of thyroid hormones, leading to low levels in the blood and decreased ability to maintain normal body metabolism. The early stages of the disease often show a ... Continue reading →

How osteoporosis affect people? Osteoporosis is a chronic bone disorder characterized by porous bones, which means that the bones have lost density and become weaker and susceptible to osteoporotic fractures. It is a condition that primarily affects people over 50, with a higher prevalence of bone density loss in women. The bones of an individual with osteoporosis may appear as a "honeycomb" structure with larger spaces between the bone tissue. It is a slow-progressing and age-related condition that increases the risk of fractures. Millions of people worldwide are affected by osteoporosis, which can significantly impact the bone health and quality of life of older adults. According to the World Health Organization (WHO), approximately 54 million Americans live with osteoporosis with significant premature bone loss.  What are osteoporosis symptoms? Osteoporosis is often referred to as a "silent disease" because many people do not experience symptoms in the ... Continue reading →

What is Influenza? Influenza, or "the Flu," is a common seasonal infection caused by RNA viruses from the Orthomyxoviridae family. There are four types of flu-causing viruses called influenza viruses: A, B, C, and D. Influenza A and B have been associated with severe epidemics with severe influenza symptoms. In contrast, influenza C causes milder respiratory infections.   What is COVID-19?   COVID-19, caused by a mutated strain of coronaviruses known as SARS-CoV-2, is a highly contagious respiratory infection that was first detected in Wuhan, China, in December 2019. Anyone can be affected by Covid-19, but the elderly and those with underlying medical conditions are at a higher risk of developing corona virus severe infections. The virus spreads from person to person through respiratory droplets and aerosols released during coughing, sneezing, breathing, or speaking. World Health Organization (WHO) declared COVID-19 a global pandemic and a public health emergency ... Continue reading →

Central BioHub is one of the largest human biospecimen marketplaces, offering a fast and efficient process that saves researchers time and effort to spot desired research samples. Using our user-friendly online marketplace, scientists worldwide can acquire clinical research specimens banked in different human biospecimens biobanks and biorepositories within minutes.  Founded in 2017, Central BioHub was founded by a group of passionate individuals with a fresh and innovative approach to revolutionizing the online biospecimen industry. We aim to connect researchers with suppliers, providing a seamless shopping experience for biosamples. We have also established the most expansive distribution network, making it easier for our customers worldwide to access our vast inventory of human biospecimens. To learn more about our platform and how we can help upgrade your biosample acquisition process, please visit our website at https://centralbiohub. ... Continue reading →

Sexually transmitted diseases (STDs) are infections spread through sexual contact with an infected partner during vaginal, anal, or oral sex. According to the World Health Organization (WHO), over a million people are newly infected with STDs daily. However, most individuals do not show symptoms and remain undiagnosed during the early stages of infection. This has led to sexual infections becoming a worldwide pandemic that affects millions of sexually active individuals, regardless of age, gender, or general health. STDs are caused by bacteria, fungi, or viruses, and common infections include syphilis, human papillomavirus (HPV), HIV/AIDS, chlamydia, gonorrhoea, trichomoniasis, hepatitis, and herpes simplex. Except for HIV/AIDS, all sexually transmitted infections can be cured with timely treatment and disease control. Unfortunately, there is currently no cure for HIV/AIDS, a deadly infection. However, practising safe and hygienic sexual behaviour is the best way to prevent ... Continue reading →

Respiratory tract infections (RTIs) are a significant health issue affecting millions worldwide. They are the primary cause of hospital admissions, ICU stays, and premature death. But what are RTIs exactly? These infections are a group of airway infections caused by bacteria, viruses, and fungi. The respiratory tract includes parts involved in breathing, such as the sinuses, throat, trachea, bronchi, and lungs. Most respiratory tract infections are highly contagious and easily spread from one person to another. They are usually droplet infections transmitted through contact with secretions during coughing, breathing, talking, sneezing, etc. Some common types of RTIs include upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), Tuberculosis, bacterial and viral pneumonia, COVID-19, Influenza (Flu), bronchitis, and bronchiolitis. Learn how to collect Respiratory biological specimens: The success of laboratory testing and in-vitro diagnostic research ... Continue reading →

Before delving into the management of human biospecimens in research, it's essential to define what these specimens are. Human biospecimens, also known as human biomaterials or human biological samples, originating from the human body, such as blood, urine, sputum, faeces, saliva, organs, teeth, hair, tissues, DNA, bones, and other materials. These biological specimens are collected from patients or donors for diagnosis, treatment, monitoring, and research purposes. Due to the perishable nature of human samples can quickly degrade or become contaminated, making it crucial to carefully manage and regulate the handling and usage of these specimens in research and development. Here are some effective ways to properly manage patient samples for research   Management of Human Biospecimens in Medical Research   Biospecimens are treated as hazardous: Human biospecimens are potentially hazardous materials that require specific handling procedures in all medical research areas. ... Continue reading →

Psoriasis is a chronic autoimmune skin disease that affects the skin, nails, and joints affecting millions of people across the globe. It is characterised by the rapid production of skin cells, accumulating on the skin's surface and causing thick, scaly, and itchy patches. Even though psoriasis is not contagious, psoriasis causes a negative impact on a person's quality of life. Psoriasis can appear at any age and is thought to affect 2-3% of people worldwide. The condition is more prevalent in adults and frequently runs in families. Although the precise cause of psoriasis is unknown, research suggests that it may be brought on by a combination of the immune system, environmental, and genetic factors. Symptoms of Psoriasis The severity and appearance of psoriasis symptoms can vary. The most typical signs are as follows: Skin lesions with red patches and thick, silvery scales Dry, bleeding skin that is cracked Stinging, burning, or discomfort Joint stiffness or pain Although ... Continue reading →