Steffan Joe

DNA damage can be referred to as any adverse alteration, which may occur in the form of base additions, base deletions or break in the sister DNA strands. Damage of genetic material is known to interfere with essential cellular processes, such as transcription and DNA replication.  DNA lesions at specific positions have been shown to be associated with the induction of heritable mutations. The accumulation of such erroneous elements in the genetic code may ultimately result in cellular aberrations, compromising structure, function, and viability. Such adverse alterations may also form the genetic basis of a variety of diseases. In fact, chromosomal aberrations and germline mutations often lead to the loss of function of tumor suppressor genes and / or those coding for essential cell cycle checkpoint proteins, which may result in uncontrollable cellular proliferation and thereby, the development of disease indications, such as cancer. To order this 130+ slides report, which ... Continue reading →

The primary purpose of this analysis was to develop a deeper understanding of the overall strength of the contract service providers involved in this field. It allows companies to compare their existing capabilities within their respective peer groups and identify ways to gain a competitive edge in the industry. In addition, this analysis can be used by the companies to ascertain improvement areas by identifying the gaps between their existing capabilities and the best available practices in the industry.   For Customize report -https://www.rootsanalysis.com/reports/cell-and-gene-therapy-bioassay-services-market/request-customization.html   In this analysis, we have compared more than 40 bioassay service providers offering services for cell and gene therapies across multiple parameters. We have analyzed all the companies and plotted a four-dimensional bubble analysis with supplier strength on the abscissa, service strength on the ordinate and service applicability as the ... Continue reading →

Digital therapeutics are clinically validated applications / software / online programs that have demonstrated the capability to facilitate positive outcomes when used in the prevention / treatment / management of diseases / clinical conditions. These therapeutics are designed to engage patients in personalized treatment or disease prevention programs, through mediating behavioral or psychological modifications, providing motivational support and inculcating healthy lifestyle changes. To order this 130+ slides report, which features 80+ figures, please visit https://www.rootsanalysis.com/reports/digital-health-market-focus-on-digital-therapeutic-monitoring-and-diag/request-customization.html     Several organizations have undertaken diverse initiatives in the field of digital therapeutics to support its growth as a new frontier in the healthcare sector. A number of organizations focused on effectively monitoring and promoting the potential of digital therapeutics to be used ... Continue reading →

Primary packaging, such as vials, syringes, and cartridges, and their affiliated closures, play a vital role in ensuring the stability, and sterility, and thereby, the overall quality, efficacy and safety of a drug product. Moreover, the packaging bears the product label, which provides information related to the drug and, in certain cases, dosing instructions. Pharmaceutical packaging is typically carried out under controlled conditions; specifically, for therapeutics that are designed for parenteral administration, fill / finish is carried out in sterile and aseptic environments. It is also crucial for innovators (or packaging service providers) to choose the appropriate, high quality primary packaging for their respective products; this is because the packaging material is in direct contact with the drug / therapy. Building and maintaining the necessary expertise and infrastructure to support pharmacological fill / finish is a capital-intensive ordeal. Further, the growing ... Continue reading →

Given the recent developments in healthcare, supporting safety and efficacy of peptide and affiliated macrocycle drugs, the industry is presently witnessing an increase in discovery and development initiatives related to such therapeutic modalities.   Roots Analysis has announced the addition of “Peptides and Macrocycle Drug Discovery: Services and Platforms Market, 2020-2030” report to its list of offerings.   The report features an extensive study on the current market landscape and future of companies offering services for peptides and macrocycle drug discovery operations. The study includes in-depth analyses, highlighting the capabilities of various service / technology providers engaged in this market. Amongst other elements, the report includes: A detailed assessment of the current market landscape of companies offering peptide and macrocycle drug discovery services An insightful geographical benchmarking of the capabilities of companies of various sizes, ... Continue reading →

The recent approval of first RNAi therapeutic, ONPATTROTM, has caused a surge in interest of the industry / non-industry players in upcoming field of pharmacological research   London   Roots Analysis has announced the addition of “RNAi Therapeutics Market (2nd Edition), 2019-2030” report to its list of offerings.   Significant advancements in the developmental pipeline across various oncological disorders, infectious diseases and genetic disorders have amplified the interest of various pharmaceutical establishments and have inspired research groups across the world, to focus their efforts on the development of RNAi therapeutics. Further, there are multiple pipeline candidates in mid to late-stage (phase II and above) trials and are anticipated to enter the market over the next 5-10 years.   To order this 350+ page report, which features 130+ figures and 190+ tables, please visit this - https://www.rootsanalysis. ... Continue reading →

The numerous benefits offered by prefilled syringes, coupled to the growing self-medication trend, have led to the approval of a number of drugs in combination with such devices, resulting in an increase in need to outsource fill / finish operations   Roots Analysis is pleased to announce the publication of its recent study, titled, “Prefilled Syringe Fill / Finish Services Market, 2020-2030.”   The report features an extensive study of the current market landscape and future opportunities for contract service providers offering fill finish services for prefilled syringes. The study features an in-depth analysis of the key drivers and trends related to this evolving domain. Amongst other elements, the report includes: A detailed review of the overall landscape of companies offering contract fill / finish services for prefilled syringes  Tabulated profiles of key players (shortlisted based on a proprietary criterion) across key geographies, such as North ... Continue reading →

Proteome profiling is a technically complex and financially demanding field of research, as a result both pharmaceutical companies and research institutes prefer to rely on specialty service providers that claim to have the required expertise   Roots Analysis is pleased to announce the publication of its recent study, titled, “Proteome Profiling Services Market, 2020-2030.”   The report features an extensive study of the current market landscape and future opportunities associated with proteome profiling service providers. The study also features a detailed analysis of the key drivers and trends related to this evolving domain. Amongst other elements, the report includes:   §  A detailed review of the overall landscape of companies offering proteome profiling services, along with information on type of service provider, year of establishment, company size, location of headquarters, service(s) offered for pre-proteome profiling, service(s) offered ... Continue reading →

A growing body of evidence suggests that using psychedelics, such as psilocybin and LSD, in combination with psychotherapy, can treat the symptoms of several mental health conditions, including depression and substance use disorders   Roots Analysis has announced the addition of “Global Psychedelic Therapeutics Market, 2020-2030” report to its list of offerings.   The report features an extensive study of the current market landscape, offering an informed opinion on the likely adoption of these therapies over the next decade. It features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain. In addition to other elements, the study includes: A detailed assessment of the current market landscape of drug developers engaged in the development of psychedelic therapeutics.  Tabulated profiles of prominent psychedelic therapeutics developers. shortlisted on the basis of the number of pipeline products). Detailed ... Continue reading →

Roots Analysis is pleased to announce the publication of its recent study, titled, “Polycystic Ovary Syndrome Market, 2021-2031.”   The report features an extensive study of the current market landscape, offering an informed opinion on the likely adoption of these therapies over the next decade. It features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain. In addition to other elements, the study includes: A detailed assessment of the therapeutic pipeline activity and therapeutic assessment of the products. Detailed profiles of the players that are engaged in the development of drug products / therapies for polycystic ovarian syndrome. An insightful market assessment summary, highlighting the clinical and commercial attractiveness of pipeline molecules (phase II and phase III). A detailed analysis identifying the key opinion leaders (KOLs), featuring a 2X2 analysis to assess the relative experience of certain KOLs. An ... Continue reading →

Recent advances in information technology and biomedical science have enabled the development of a number of versatile digital solutions that are capable of either mimicking or augmenting, the fundamental qualities of pharmacological interventions.   Roots Analysis is pleased to announce the publication of its recent study titled, “Digital Health Market: Focus on Digital Therapeutics (2nd Edition), 2020-2030 (Based on Type of Solution (Software Solution, Gaming Solution and Combination Solution), Type of Therapy (Curative and Preventive), and Purpose of Solution (Medication Replacement and Medication Augmentation   The report features an extensive study of the current market landscape, offering an informed opinion on the likely adoption of these solutions over the next decade. The report features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain. Amongst other elements, the report includes:   A detailed assessment ... Continue reading →

Driven by the potential to confer sustained therapeutic effects and thereby, facilitate prolonged periods of remission, TIL-based therapies have received significant financial support, and promising leads are poised to soon achieve blockbuster status   Roots Analysis has announced the addition of “TIL-based Therapies Market, 2021-2030” report to its list of offerings.   Given the frequently reported inadequacies of conventional cancer therapies and the growing need for personalized medicine, there is a marked surge in the demand for TIL-based therapies. In addition, the clinical success in this domain is likely to draw in investments that will support ongoing and anticipated therapy development initiatives.   To order this 255+ page report, which features 90+ figures and 100+ tables, please visit https://www.rootsanalysis.com/reports/til-therapies-market.html   Key Market Insights   Over 80 TIL-based therapies are currently under development Close ... Continue reading →

To order this detailed 250+ page report, please visit this - https://www.rootsanalysis.com/reports/drug-repurposing-service-provides.html   Key Inclusions A detailed assessment of the current market landscape of companies offering drug repurposing services based on several relevant parameters, including year of establishment, company size, location of headquarters, type of company, type of service offered (drug discovery, consulting and others), purpose of repurposing, type of repurposing and technology platform used. A detailed analysis of the various partnerships that have been signed within this domain, during the period 2013-2020, along with information on year of partnership, type of partnership, and partner company, type of technology / platform used, and key value drivers (such as target therapeutic area and type of drug molecule) and location of collaborators. A review of recent initiatives undertaken by big pharma players across the globe for the discovery and ... Continue reading →

Owing to their cost and time saving potential, in silico tools are widely used in modern pharmacological research; several companies have developed novel tools, which are specifically designed to accelerate and augment the drug discovery process.     Roots Analysis has announced the addition of “In Silico / Computer-Aided Drug Discovery Services Market: Focus on Large Molecules (Antibodies, Proteins, Peptides, Nucleic Acid, Gene Therapy and Vectors), 2020-2030 (Including Structure Based Drug Discovery, Fragment Based Drug Discovery, Ligand Based Drug Discovery, Target Based Drug Discovery / Multi-Target Drug Design, Interface Based Drug Discovery, Approaches)” report to its list of offerings.   Presently, in silico tools / approaches are available for the identification, selection and optimization of pharmacological leads. in fact, the predictive power of such solutions has been demonstrated to enable researchers to bypass the traditional experimental ... Continue reading →

Drug discovery is challenging and involves several complexities. In order to continue to add new molecules their pipelines, drug developers are opting to outsource such operations to contract research organizations (CROs). Outsourcing of peptides and macrocycle drug discovery has emerged as one of the recent trends in the overall pharmaceutical domain.   To order this 180+ page report, which features 90+ figures and 85+ tables, please visit this - https://www.rootsanalysis.com/reports/view_document/peptides-and-macrocycle-discovery/300.html   The USD 1.5 billion (by 2030) financial opportunity within the peptides and macrocycles drug discovery service and platform providers market has been analyzed across the following segments: Type of peptides Synthetic peptides Biologic and recombinant peptides   Type of discovery steps Target identification and validation Hit identification Lead generation Lead optimization   Therapeutic Area Oncological disorders Metabolic ... Continue reading →

Roots Analysis has done a detailed report on Subcutaneous Biologics, Technologies and Drug Delivery Systems (3rd Edition), 2020-2030 covering key aspects of the industry and identifying future growth opportunities   To order this 530+ page report, which features 160+ figures and 190+ tables, please visit Subcutaneous Biologics, Technologies and Drug Delivery Systems (3rd Edition), 2020-2030   Key Market Insights Eminent representatives from biopharmaceutical companies confirm the rising interest in the concept of subcutaneous drug delivery, highlighting some of the key drivers and upcoming trends in this domain More than 100 subcutaneous biologics have been approved and over 350 such drug candidates are being evaluated in the clinical stages of development, for the treatment of a wide variety of disease indications Antibodies and protein therapeutics represent the majority of subcutaneous biologics that are available / under investigation, designed for use against various ... Continue reading →

Roots Analysis has done a detailed study on “Synthetic Lethality-based Drugs and Targets Market, 2019-2030: Focus on DNA Repair (including PARP Inhibitors) and Other Novel Cellular Pathways” covering key aspects of the industry’s evolution and identifying potential future growth opportunities.   To order this 485+ page report, which features 195+ figures and 200+ tables, please visit Synthetic Lethality-based Drugs and Targets Market, 2019-2030: Focus on DNA Repair (including PARP Inhibitors) and Other Novel Cellular Pathways   Key Market Insights An analysis of recent activity on Twitter confirms the rising interest in this domain as stakeholders attempt to harness the therapeutic potential of synthetic lethality About 75 drug candidates based on synlet gene pairs are being evaluated for the treatment of various types of cancers; presently, there are over 20 screening platforms enabling therapy development efforts The pipeline features both small molecules ... Continue reading →

The concept of targeted protein degradation presents revolutionary drug development opportunities and is anticipated to bring about a paradigm shift in modern healthcare. The first targeted protein degrader, called proteolysis targeting chimera (PROTAC), was developed about a decade ago. Presently, a variety of other such chemical entities and molecular glues are under investigation. In fact, certain pipeline candidates are already in the mid to late-phase trials and are anticipated to soon enter the market.   To order this 330+ page report, which features 130+ figures and 145+ tables, please visit https://www.rootsanalysis.com/reports/view_document/protein-degradation-market/289.html   The USD 3.6 billion (by 2030) financial opportunity within the target protein degradation market has been analyzed across the following segments: Type of payment of licensing agreements Upfront payments Milestone payments   Type of protein degrader Degronimids PROTACs SARDs / SERDs ... Continue reading →

Advances in biotechnology have enabled the identification of several novel biomarkers, which are presently being used for a variety of purposes, including diagnosis, drug development, clinical research and to facilitate therapy-related decisions   Roots Analysis is pleased to announce the publication of its recent study, titled, “Cancer Biomarkers Market: Focus on TMB, MSI / MMR and TILs Testing, 2019–2030.”   The report features an extensive study of the current landscape and future outlook of the immuno-oncology biomarkers testing market (focusing particularly on TMB, MSI and TILs (CD3+, CD4+, CD8+, FOXP3+)). It provides an in-depth analysis, highlighting the capabilities of the various companies engaged in this domain. Amongst various elements, the report includes: A detailed analysis of ongoing, biomarker-based clinical trials initiated by big pharmaceutical companies.  An analysis of the landscape of companies offering testing services for cancer ... Continue reading →

Advances in biotechnology have enabled the development of versatile in vitro (static and dynamic), in vivo (micro-dialysis), and in situ (brain perfusion) blood–brain barrier models, allowing more effective and safe delivery of drugs across brain capillaries   Roots Analysis is pleased to announce the publication of its recent study, titled, “Blood-Brain Barrier (BBB) Market (2nd Edition), 2020-2030: Focus on Non-Invasive Drug Delivery Technology Platforms and Therapeutics.”   The report features an extensive study of the current market landscape, offering an informed opinion on the likely adoption of BBB penetration technologies and affiliated drugs, over the next decade. The report features an in-depth analysis, highlighting the diverse capabilities of stakeholders engaged in this domain. In addition to other elements, the study includes: §  An overview of the overall landscape of BBB penetration technologies, featuring an in-depth analysis of ... Continue reading →