Physician-scientists in the Cancer Center at Children’s Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.
The researchers published their findings today in Science Translational Medicine.
In 2008, researchers discovered mutations in the anaplastic lymphoma kinase (ALK) gene as the major cause of the inherited form of neuroblastoma and showed that these same mutations are present in about 14 percent of neuroblastoma tumors from patients with the most aggressive form of this disease. This established ALK as a druggable target in neuroblastoma and provided the rationale for the clinical development of ALK inhibition therapy. It was found that native ALK (in the absence of a mutation) is present on most neuroblastoma tumors, providing us with an exciting opportunity to target ALK in the majority of patients.
Neuroblastoma, a pediatric cancer of the developing peripheral nervous system that usually occurs as a solid tumor in a child’s chest or abdomen, is the most common cancer in infants, and accounts for more than 10 percent of all childhood cancer deaths. Children with the high-risk form of the disease continue to have a poor prognosis, despite intensive drug therapy.
Mossé, a pediatric oncologist and researcher at CHOP along with other scientists in her lab, demonstrated that the ALK protein appears on the surface of most neuroblastoma cells and is not detectable on normal cells, indicating that ALK is a useful target for immunotherapy. Researchers worked with pharmaceutical colleagues to weaponize an antibody-drug conjugate (ADC), one of a rapidly growing class of anticancer agents. That ADC, called CDX-0125-TEI, combines a specific monoclonal antibody engineered to recognize ALK with a potent chemotherapy drug—an alkylating agent called thienoindole (TEI).
In cell cultures and animal models of neuroblastoma, the ADC-ALK approach killed neuroblastoma cells, with no discernible toxicity to healthy cells. “The goal of this approach is to harness the presence of ALK to precisely deliver a poison only to the cancer cell, without harming the healthy surrounding cells,” said Mossé.
“This study is proof of concept that the ALK protein is a good immunotherapy target and, as we optimize this approach for the clinic, has the potential to be useful for the majority of aggressive neuroblastomas and to minimize the harsh consequences of therapy,” said Mossé.
She added, “In addition, our research could have great relevance for other cutting-edge immunotherapeutic strategies, such as CAR T-cell therapy, that harness the immune system to kill cancer, and is currently showing tremendous efficacy in children with leukemia. Our new data support clinical development of an immunotherapy drug not just for neuroblastoma, but for other hard-to-cure childhood cancers expressing the ALK gene, including rhabdomyosarcomas.”
Biochempeg provides GMP standard PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. Biochempeg is dedicated to providing a chemical synthesis and high-quality ADC linkers. ADC linkers with molecular weights, branching, and functional groups not listed in our online catalog may be available by custom synthesis.
Article source: https://article-realm.com/article/Finance/16063-ADC-Has-Curative-Effect-On-Cell-Surface-Protein-In-Neuroblastoma.html
Reviews
Comments
Most Recent Articles
- Sep 13, 2024 Why SIP in ELSS is a Win-Win for Tax Saving and Wealth Creation by sandeepkumar
- Sep 12, 2024 How Does the Portfolio Overlap Tool Work in Top Mutual Fund Software in India? by Wealth Elite
- Sep 5, 2024 Wealth management versus financial planning by Anna Paquin
- Sep 2, 2024 How Does the Compare Funds Feature in Mutual Fund Software Work? by Wealth Elite
- Aug 29, 2024 How Mutual Fund Software for IFA Helps in Selecting the Right Mutual Fund for Investors? by Wealth Elite
Most Viewed Articles
- 11084 hits How to Start an Invention Idea by Edwin Poul
- 9063 hits How to Download and Install Facebook Messenger on Firestick by Hope Mikaelson
- 2607 hits Brief discussion about Water by kavin prasath
- 2114 hits Importance of Proofreading While You Write an Assignment by clara
- 1891 hits Sleeping Pillow Market by Trisha Kumari
Popular Articles
In today’s competitive world, one must be knowledgeable about the latest online business that works effectively through seo services....
77365 Views
Are you caught in between seo companies introduced by a friend, researched by you, or advertised by a particular site? If that is the...
32685 Views
Walmart is being sued by a customer alleging racial discrimination. The customer who has filed a lawsuit against the retailer claims that it...
13679 Views
If you have an idea for a new product, you can start by performing a patent search. This will help you decide whether your idea could become the...
11084 Views
Statistics
Members | |
---|---|
Members: | 15316 |
Publishing | |
---|---|
Articles: | 63,054 |
Categories: | 202 |
Online | |
---|---|
Active Users: | 656 |
Members: | 7 |
Guests: | 649 |
Bots: | 8392 |
Visits last 24h (live): | 2155 |
Visits last 24h (bots): | 23868 |