Is There A Link Between COVID-19 And Parkinson's Disease Article Realm.com Free Article Directory

Featured Articles

In today’s competitive world, one must be knowledgeable about the latest online bus...

Oct 12, 2018

by Sunny Fang on Dec 22, 2021 Finance 495 Views

Case reports of younger COVID-19 patients developing Parkinson’s disease within weeks of contracting the virus led researchers to investigate a possible link between the two conditions.

Scientists recently demonstrated that, in the test tube, the SARS-CoV-2 N-protein interacts with a neuronal protein known as α-synuclein and boosts the development of amyloid fibrils—the pathological protein bundles characteristic of Parkinson’s disease.

Along with causing respiratory symptoms, SARS-CoV-2 can induce neurological problems, like headaches, loss of smell, and “brain fog.” However, it is still controversial if these symptoms are caused by the virus penetrating the brain, or if the symptoms are due to chemical signals released in the brain by the immune system as a response to the virus.

In Parkinson’s disease, a protein known as α-synuclein develops abnormal amyloid fibrils, which leads to the death of dopamine-producing neurons in the brain. Intriguingly, in Parkinson’s disease, loss of smell is a usual premotor symptom.

This fact along with case reports of Parkinson’s in COVID-19 patients led Christian Blum, Mireille Claessens, and coworkers to wonder if the protein components of SARS-CoV-2 could induce the accumulation of α-synuclein into amyloid.

The researchers analyzed the two abundant proteins of the virus—the spike (S-) protein that facilitates the entry of SARS-CoV-2 into the cells and the nucleocapsid (N-) protein that encapsulates the RNA genome within the virus.

The researchers performed test tube experiments where they utilized a fluorescent probe that attaches amyloid fibrils to demonstrate that—in the absence of the coronavirus proteins—α-synuclein needed over 240 hours to aggregate into fibrils. When the S-protein was added, the researchers found no effects, however, the N-protein reduced the aggregation time to less than 24 hours.

The researchers carried out other experiments to demonstrate that the N- and α-synuclein proteins interact directly. The interaction is partly due to their opposite electrostatic charges, with around 3–4 copies of α-synuclein linked to each N-protein.

The scientists later injected the fluorescently labeled α-synuclein and N-protein into a cell model of Parkinson’s disease which contained the same concentration of N-protein that would be seen inside a SARS-CoV-2-infected cell.

Twice as many cells died when injected with both proteins compared to control cells with only α-synuclein injected. It was also found that the distribution of α-synuclein was changed in cells co-injected with both proteins.

The researchers observed elongated structures even though they could not confirm that they were amyloid. The researchers state that they are unsure if these interactions take place inside neurons of the human brain, however, if that is the case, it could illustrate the possible connection between COVID-19 infection and Parkinson’s disease.

As a leading supplier of PEG derivatives and pharmaceutical intermediates, Huateng Pharma suppliesCAS NO.27514-08-5 & CAS NO.104617-49-4 & CAS NO.106092-09-5 with best price and high quality, they are intermediate of Pramipexole for Parkinson's disease.It also supplies somePEG products used in COVID-19 mRNA vaccines, such as DSPA, mPEG-DSPE, mPEG-DTA (ALC-0159) and so on.

Article source: https://article-realm.com/article/Finance/18007-Is-There-A-Link-Between-COVID-19-And-Parkinsons-Disease.html

General
Link

Comments

No comments have been left here yet. Be the first who will do it.

Reviews

Guest

Most Recent Articles

Oct 21, 2026 Want to Start an SIP? Get Free SIP Investment Advice Before You Invest by MunafaWaala
Sep 24, 2026 Get Free Retirement Planning Advice and Build a Better Financial Future by MunafaWaala
Sep 15, 2026 Get Free Mutual Fund Advisory: How to Choose Investments Based on Your Goals by MunafaWaala
Jul 15, 2026 FIN Group Launches Reg Review: AI-Powered Compliance Platform for Investment Advisers, etc by Dinesh Kumar
Jul 1, 2026 Why Should You Use a Financial Advisor for SIP Investment? by MunafaWaala

Statistics

Members
Members:	17293

Publishing
Articles:	80,064
Categories:	202

Online
Active Users:	1921
Members:	0
Guests:	1921
Bots:	10428
Visits last 24h (live):	6598
Visits last 24h (bots):	33449

Latest Comments

I really loved reading your blog. It was very well authored and easy to undertand. Unlike additional blogs I have read which are really not tht good. I also found your posts very interesting. In...

on Nov 15, 2026 about Aircon Issues That Require A Crisis Fix

I appreciate the way this content avoids unnecessary fluff. It’s straightforward and to the point while still offering depth. That economy of words without sacrificing meaning is a true skill...

on Nov 15, 2026 about 8 Effective Strategies for Maximizing ROI with Local Classified Ads

Very good points you wrote here..Great stuff...I think you've made some truly interesting points.Keep up the good work. 베트맨 도메인 주소

on Nov 15, 2026 about Aircon Issues That Require A Crisis Fix

Good to become visiting your weblog again, it has been months for me. Nicely this article that i've been waited for so long. I will need this post to total my assignment in the college, and it has...

on Nov 15, 2026 about Aircon Issues That Require A Crisis Fix

What a fantabulous post this has been. Never seen this kind of useful post. I am grateful to you and expect more number of posts like these. Thank you very much. 판타스틱벳

on Nov 15, 2026 about Aircon Issues That Require A Crisis Fix

I can’t believe focusing long enough to research; much less write this kind of article. You’ve outdone yourself with this material without a doubt. It is one of the greatest contents. 뽀빠이벳

on Nov 14, 2026 about Aircon Issues That Require A Crisis Fix

Wonderful blog! I found it while surfing around on Yahoo News. Do you have any suggestions on how to get listed in Yahoo News? I’ve been trying for a while but I never seem to get there!...

on Nov 14, 2026 about Aircon Issues That Require A Crisis Fix

Very nice article. I enjoyed reading your post. very nice share. I want to twit this to my followers. Thanks !. 텐텐벳 주소

on Nov 14, 2026 about Aircon Issues That Require A Crisis Fix

Finding your account information is even easier shopping at Target! Sign in securely to Target Red Card Login to see your recent transactions, payments, and card activity.

on Nov 14, 2026 about How To Succeed At Internet Marketing

This article offers practical advice on moving blankets and accessories. Understanding how plastic wraps and moving straps enhance protection is key. For those tricky moves, like downhill with...

on Nov 13, 2026 about How to Use Moving Blankets to Protect Your Items When Moving