Chemical Products 2-Thiopheneethanol Production Methods

Chemical Products 2-Thiopheneethanol Description
clear colorless to slightly brown liquid

Chemical Products 2-Thiopheneethanol Basic Attributes
CAS No：5402-55-1

Molecular Formula ：C6H8OS

Molecular Mass ：128.19

Exact Mass ：128.029587

PSA ：48.5 A^2

LogP ：1.3

EINECS ：226-452-0

InChIKeys ：VMJOFTHFJMLIKL-UHFFFAOYSA-N

H-bond Acceptor ：2

H-bond Donor ：1

SP3 ：0.33

RBN ：2

Chemical Products 2-Thiopheneethanol Characteristics
Appearance ：Clear light yellow to gray-green or brownish Liquid

Density ：1.153 g/mL at 25 °C(lit.)

Bolling Point ：108-109 °C13 mm Hg(lit.)

Flash Point ：214 °F

Refractive Index ：n20/D 1.551(lit.)

Solubility ：slightly soluble

Storage Condition ：Store below +30°C.

BRN ：106985

Chemical Products 2-Thiopheneethanol Safety Information
HS Code ：29349990

UN No. ：UN 3334

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：23-24/25-36-26

Dangerous Mark ：Xi

P Code ：P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements ：H302

Hazard Note ：Irritant

Chemical Products 2-Thiopheneethanol Product Usage
2-Thiopheneethanol is a thiophene derivative used in the preparation of oligothiophene isothiocyanates as fluorescent markers for biopolymers. 2-Thiopheneethanol is also used in the preparation of other biologically active compounds such as the analgesic Sulfentanyl and the antithrombotic Clopidogrel Hydrogen Sulfate (C587250).

Chemical Products 2-Thiopheneethanol Production Methods
Biotransformation experimentsFungal strains were pre-grown in Petri dishes containing maltextract solid medium (MEA: 20 g L−1 glucose, 20 g L−1 malt extract,20 g L−1 agar, 2 g L−1 peptone) from which the inoculum for liquidcultures was set up. The fungus was inoculated as conidia suspen-sion (1 106 conidia/mL) in 50 mL asks containing 40 mL of maltextract liquid medium. Flasks were incubated at 25 C and weremaintained under agitation (110 rpm).After 2 days of pre-growth, a 500 mM solution of the substratein DMSO was added, to a starting substrate concentration (c0) of1–5 mM. For each substrate, three biological replicates were run.The experiment was run for 3 days after the addition of the sub-strates, during which time 1 mL samples were taken, at speciedintervals (usually 24, 48, and 72 h). Each sample was extractedwith EtOAc (500 L), the organic phase was dried over anhydrousNa2SO4 and analysed by means of GC/MS.

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