Chemical Products FMOC-L-Leucine Production Methods

CAS No:35661-60-0
Formula:C21H23NO4
Synonyms:FMOC-LEU-OH;FMOC-L-LEU-OH;FMOC-L-LEU;FMOC-L-LEUCINE;F-L-LEU;Fmoc-L-leucine,98%;L-Leucine-1-13C-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine
China Export:From 2018.11 to 2019.11, total export volume of FMOC-L-Leucine from China was 76,865,630KG while total export value was $825,816,556. The biggest proportion of exporting volume in the last 12 months was 14.24% in 2019.05.

Chemical Products FMOC-L-Leucine Description
white to light yellow crystal powde

Chemical Products FMOC-L-Leucine Basic Attributes
CAS No：35661-60-0

Molecular Formula ：C21H23NO4

Molecular Mass ：353.41

Exact Mass ：353.162720

PSA ：75.6 A^2

LogP ：4.4

EINECS ：252-662-7

InChIKeys ：CBPJQFCAFFNICX-IBGZPJMESA-N

H-bond Acceptor ：4

H-bond Donor ：2

SP3 ：0.33

RBN ：7

Chemical Products FMOC-L-Leucine Characteristics
Density ：1.2±0.1 g/cm3

Melting Point ：152-156 °C(lit.)

Bolling Point ：559.8°C at 760 mmHg

Flash Point ：292.4±25.4 °C

Refractive Index ：1.583

Storage Condition ：2-8°C

BRN ：2178254

Specific Rotation ：-26 º (c=1,DMF 24 ºC)

Chemical Products FMOC-L-Leucine Safety Information
HS Code ：2924299090

UN No. ：NONH for all modes of transport

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：22-24/25-36/37/39-27-26

Dangerous Mark ：Xi

P Code ：P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements ：H302

Chemical Products FMOC-L-Leucine Production Methods
General procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.EXAMPLE 22

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