Echemi Europe B.V. Study: high-dose vitamin D can slow down aging and frailty

Echemi Europe B.V. a small study of mice has shown that vitamin D is five times the recommended dose for the elderly, which may slow the development of frailty. However, researchers now need to confirm this finding in humans.

At present, if a person shows three or more of the following five characteristics, doctors will define him as a "weak person":

Unexpected weight loss, weak grip, self-reported fatigue, low level of physical activity, slow walking speed.

Vulnerability tends to increase with age, affecting about half of people over the age of 85. It is associated with disability, loss of independence and rising mortality.

Echemi Europe B.V. Studies have shown that people with low levels of vitamin D in their blood are more vulnerable. This is a particularly urgent problem, as there may be one billion people worldwide who do not have adequate vitamin D levels.

Adequate vitamin D has many health benefits, including bone and tooth health, and increased immunity to respiratory infections.

When the skin is exposed to ultraviolet light in the sun, the body can synthesize vitamin D by itself. However, in winter at high latitudes, for people who spend most of their time indoors, the main source of vitamin D is diet and supplements.

Optimal intake

There is still some uncertainty about how much vitamin D a person should take.

The National College of Medicine recommends that adults aged 19 to 70 take 600 international units (IU) a day, and those over 70 take 800 IU a day.

According to a team from the Department of Veterans Affairs, New York, Western New York health care system and the University of buffalo, these recommendations are based primarily on optimizing bone health.

They believe that in order to maintain muscle strength and prevent muscle weakness, higher levels are needed.

In their previous study, in "middle-aged" mice, chronic vitamin D deficiency may lead to impaired anaerobic exercise capacity, decreased muscle mass, and increased fat or adipose tissue.

Their latest study on mice was published in the journal. Nutrients suggest that the lack of adequate vitamins in the elderly may accelerate physical development.

Dr Kenneth L seldeen, the lead author of the study, said: "we found that in older mice, vitamin D levels were too low, leading to decreased body function, grip strength and grip strength - the ability to maintain control - and they started to develop a reduction in vitamin D intake within a month."

Crucially, vitamin D can protect mice from these effects only if it is several times the recommended intake for older people.

"To slow the development of frailty, it actually needs more vitamin D than is now thought to be enough for a person," serdin said

"Overestimation" intake

The scientists monitored 24-28 month old mice, the equivalent of 65-80 year old humans. At the beginning of the study, they divided the animals into three groups:

Insufficient vitamin D intake (defined as 125 IU / kg feed) "excessive" intake (8000 IU / kg feed)

Over the next four months, they evaluated the physical performance of the animals and scored them on five tests, which are equivalent to the tests doctors use to evaluate humans.

By the end of the study, mice with insufficient or insufficient vitamin D intake were much weaker than at the beginning of the experiment.

In contrast, mice with excessive intake were slightly weaker at the end of the study, but the increase was not statistically significant.

It is worth noting that, despite the increase in the vulnerability index, four months later, none of the mice met the researchers' definition of vulnerability.

The researchers recommend that the elderly take at least 2000 IU of vitamin D a day.

Senior research author Dr. Bruce R. "It's especially important for our frail elderly patients," tren said "But based on our research, we believe that proper vitamin D supplementation over a lifetime will optimize long-term functional capacity and health."

The new study shows that a maximum daily dose of 4000 IU is a safety limit considered by the National Academy of Medical Sciences, which is necessary to delay the development of frailty in the elderly.

0.025 microgram of vitamin D is added to the dose equivalent to 1 IU, so 4000 IU is equivalent to 100 microgram.

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