4-Dialkylaminopyridines have applicability for catalysis of a wide variety of chemical reactions

4-Dimethylaminopyridine Description

4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of chemical reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978. [3] The accelerating pace of reported applications for DMAP and the availability of DMAP in commercial quantities, at modest prices, have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemist

Basic Attributes

CAS No：1122-58-3

Molecular Formula ：C7H10N2

Molecular Mass ：122.16800

Exact Mass ：122.08400

PSA ：16.13000

InChIKeys ：VHYFNPMBLIVWCW-UHFFFAOYSA-N

H-bond Acceptor ：2

H-bond Donor ：0

SP3 ：0.29

RBN ：1

Characteristics

Density ：1.012 g/cm3

Melting Point ：108-113ºC

Bolling Point ：162ºC (50 mmHg)

Flash Point ：110ºC

Refractive Index ：n20/D 1.431

Solubility ：76 g/L (25 ºC)

Storage Condition ：Store in dark

Vapor Pressure ：0.431mmHg at 25°C

Stability ：Stable. Incompatible with acids, oxidizing agents.

Safety Information

Packing Group ：II

Hazard Class ：8

HS Code ：2933399090

UN No. ：UN 1760/2811

WGK_Germany ：3

Risk Code ：R24/25; R34

Safety Instructions ：S26-S28-S36/37/39-S45

RTECS No. ：US8400000

Dangerous Mark ：T

P Code ：Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P305 + P351 + P338-P361 + P364

Hazard Statements ：H301-H310-H315-H319-H335

Toxicity ：LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg

4-Dimethylaminopyridine Chemical Product Usage

1. A highly efficient catalyst for acylation reactions.
2. 4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to improve the yield, reduce the reaction time, improving relaxation process conditions. Widely used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a blowing catalyst.
3. DMAP is a useful highly basic nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement.
4. A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite protected form, can be site-specifically inserted into oligonucleotides through a 3?5?phosphodiester linkage using an automated DNA synthesizer

Material and Products

Material ：Methanol Reagent, LITHIUMDIMETHYLAMIDE, 4-DIMETHYLAMINOPYRIDINEN-OXIDE, 3-Nitroaniline, N-(4-Pyridyl)pyridiniumchloridehydrochloride, Dimethylamine, guanidine, 4-Chloropyridiniumchloride, 1,2,4-Triazine, Dimethylamine hydrochloride, 2,4-Pentanedione, 4-chloropyridine, 4-Cyanopyridine, PHENYLSILANE, 4-Aminopyridine, N,N-Dimethylformamide, 4-Phenoxypyridine, 4-MethoxypyridineN-oxide, 4-Methoxypyridine, 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE

Products ：Phthalic Anhydride, Paclitaxel, Formaldehyde, Piperidine, PHENYLSILANE, N,N'-DICYCLOHEXYLUREA, 2,6-PYRIDINEDICARBOXAMIDE, Pyridinehydrochloride, Benzylether, (S)-N-Boc-1-Naphthylalanine, 4,6-Dichloropyrimidine, 2-Amino-5-bromo-4,6-dimethylpyrimidine, 4-DIMETHYLAMINOPYRIDINEN-OXIDE, 2-Acetamido-5-nitropyridine, N-Phenylhydroxylamine, Isoquinoline, 5-ACETOXYMETHYL-2-FURANCARBOXYLIC ACID, 2-Bromo-4-dimethylaminopyridine, N,N-Dimethylpiperidin-4-amine, N-Methyl-4-pyridinamine

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